I'd like to give a huge thank you to my Houston CHW friends, who have posed some very interesting questions. (I'm sorry you were not able to post the comments, and I have changed my blog settings to make that process easier).
First, regarding the B-vitamins: There is some controversy over what constitutes a "high dose" of folic acid, but doses over 400 mcg have been associated with a higher risk for blockages of stents that are implanted in the heart arteries, as well as a higher risk for some forms of cancer. Having said that, pregnant women often require higher doses, since folic acid is important in helping the grow the nervous system in a developing fetus. Certain medications (for example, the drug methotrexate) deplete the body's supplies of folic acid, so in this case, doctors will usually prescribe high supplemental doses. If you have any questions about what is right for you, always ask your doctor.
High doses of B12 are generally considered to be doses of 400 mcg or more, and for B6, 40 mg, although less is known about the effects of high doses of these vitamins. If you suspect you have a B12 deficiency, ask your doctor for a blood test. Birth control pills can deplete these vitamins, as can menstruation, but most women can get enough B vitamins from their diets.
In regards to the question about the connection between fructose and pancreatic cancer, there does indeed appear to be a relationship. Although the research is not definitive, it is best to avoid high fructose corn syrup for many reasons, not the least of which is the extra, empty calories that our bodies simply don't need.
I hope I've helped to answer your questions. Please feel free to contact me via the blog, and let me know if there are any topics that you would like me to cover. I'd love to hear from you!
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